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PROCARDIA regularly reduces arterial pressure at rest and at a given level of exercise by dilating peripheral arterioles and reducing the total peripheral resistance (afterload) against which the heart works. This unloading of the heart reduces myocardial energy consumption and oxygen requirements and probably accounts for the effectiveness of PROCARDIA in chronic stable angina.
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The dosage is based on your medical condition and response to treatment. Your doctor may gradually increase your dose. Follow your doctor’s instructions carefully.
PROCARDIA.like other calcium channel blockers.decreases platelet aggregation in vitro . Limited clinical studies have demonstrated a moderate but statistically significant decrease in platelet aggregation and an increase in bleeding time in some PROCARDIA patients. This is thought to be a function of inhibition of calcium transport across the platelet membrane. No clinical significance for these findings has been demonstrated.
There are no adequate and well-controlled studies cheap procardia pregnant women. Procardia should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom Procardia was administered. However.the relationship to Procardia therapy is uncertain.
Age appears to have a significant effect on the pharmacokinetics cheap procardia nifedipine. The clearance is decreased resulting in a higher AUC in the elderly. These changes are not due to changes in renal function (see CLINICAL PHARMACOLOGY .Pharmacokinetics ).
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