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The extent of systemic exposure to selegiline at a given dose varies considerably among individuals. Estimates of systemic clearance of selegiline are not available. Following a single oral dose.the mean elimination half-life of selegiline is two hours. Under steady state conditions the elimination half-life increases to ten hours.
Patients should be monitored closely for changes in behavior.clinical worsening.and suicidal tendencies. this should be done during how much eldepryl 1-2 months of therapy and dosage adjustments.
In children and young adults.risks must be weighed against the benefits of taking antidepressants.
Evidence supporting how much eldepryl claim was obtained in randomized controlled clinical investigations that compared the effects of added selegiline or placebo in patients receiving levodopa/carbidopa. Selegiline was significantly superior to placebo on all three principal outcome measures employed. change from baseline in daily levodopa/carbidopa dose.the amount of ‘off’ time.and patient self-rating of treatment success. Beneficial effects were also observed on other measures of treatment success (e.g..measures of reduced end of dose akinesia.decreased tremor and sialorrhea.improved speech and dressing ability and improved overall disability as assessed by walking and comparison to previous state).
Get emergency help immediately if any of the following symptoms of overdose occur while taking selegiline.
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